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Acyclovir and hydrocortisone (Topical application)

Generic name: acyclovir and hydrocortisone [ ay-SYE-kloe-vir, hye-droe-KOR-ti-sone ]
Brand name: Xerese
Drug class: Topical steroids with anti-infectives

Medically reviewed by Drugs.com. Last updated on Aug 10, 2023.

Uses for acyclovir and hydrocortisone

Acyclovir and hydrocortisone topical combination is used to treat the symptoms of herpes simplex virus infection on the lips and around the mouth (cold sores). Although this medicine will not cure herpes simplex, it may help the sores to heal faster and relieve some of the pain and discomfort. Acyclovir is an antiviral agent (treats a virus) and hydrocortisone is a steroid (cortisone-like) medicine.

This medicine is available only with your doctor's prescription.

Before using acyclovir and hydrocortisone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of acyclovir and hydrocortisone topical combination in children younger than 6 years of age. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of acyclovir and hydrocortisone topical combination have not been performed in the geriatric population, no geriatric-specific problems have been documented to date.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper use of acyclovir and hydrocortisone

Use this medicine only as directed by your doctor to benefit your condition as much as possible. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

This medicine is only for cold sores on the lips and around the mouth. Do not get it in your eyes, inside your mouth or nose, or on the genital area. If the cream does get on these areas, rinse it off with water right away.

To help clear up your herpes infection, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. Do not miss any doses.

To use:

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions while using acyclovir and hydrocortisone

It is very important that your doctor check your progress after you use this medicine to see if the medicine is working properly.

If your symptoms do not improve within 2 weeks, or if they become worse, check with your doctor.

Do not use cosmetics or other skin care products (eg, make-up, sun screen, lip balm) on the treated area.

Side Effects of acyclovir and hydrocortisone

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Incidence not known

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Commonly used brand name(s)

In the U.S.

Available Dosage Forms:

Therapeutic Class: Antiviral

Pharmacologic Class: Viral DNA Polymerase Inhibitor

Chemical Class: Guanosine Nucleoside Analog

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.